Faculty Profile

Maria-Luisa Alegre
Section of Rheumatology
Professor of Medicine

Academic Interests

Dr. Alegre is interested in T cell tolerance. She studies peripheral mechanisms that contribute to inhibiting T cell activation such as CD4+/CD25+ regulatory T cells and surface receptors that limit T cell expansion (CTLA-4 and PD-1). She has shown that cross linking or over expression of CTLA-4 can reduce allograft rejection and prevent autoimmunity in animal models. She is currently studying the role of NF- B activation in T cells in autoimmunity models.

Clinical Interests



For a complete list of publications click here:


  • BS, 1981, Universite Libre de Bruxelles, Medical Sciences
  • MD, 1985, Universite Libre de Bruxelles
  • Residency, 1989, Universite Libre de Bruxelles, Internal Medicine
  • PhD, 1993, The University of Chicago, Immunology
  • Fellowship, 1995, Universite Libre de Bruxelles, Intensive Care
  • Fellowship, 1998, The University of Chicago, Immunology