Faculty Profile

Manami Hara
Section of Endocrinology, Diabetes and Metabolism
Research Professor

Academic Interests

Dr. Hara's research focus is on the developmental biology of pancreatic islets. The islet of Langerhans is a micro-organ composed of insulin-secreting beta-cells and other endocrine cells that work together to maintain glucose homeostasis. Using novel mouse models combined with sophisticated imaging techniques of the whole mouse pancreas, we have proposed a new model of islet formation including mathematical modeling. Ongoing studies include the islet development in large animals (pigs, monkeys and humans) as well as the pathogenesis of disease states such as type 1, type 2 and early-onset diabetes

Clinical Interests



  • Hara, M., Yin, D., Dizon, R.F., Shen, J., Chong, A.S., and Bindokas V.P. A mouse model for studying intrahepatic islet transplantation. Transplantation 78: 615-618, 2004
  • Hara, M., Bindokas, V.P., Lopez, J., Kaihara, K., Landa Jr., L.R., Harbeck, M., and Roe M.W. Transgenic expression of a fluorescent calcium biosensor in mice. Am. J. Physiol. Cell Physiol. 287: C932-938, 2004
  • Alcoser S.Y., Hara, M., and Ehrmann, D.A. Association of the ARE polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 89: 2973-2976, 2004
  • Reutrakul, S., Hathout E.H., Janner, D., Hara, M., Donfack, J., and Refetoff S. Familial juvenile autoimmune hypothyroidism, pituitary enlargement, obesity and insulin resistance. Thyroid. 14:311-319, 20
  • Kojima, H., Fujimiya, M., Matsumura, K., Nakahara, T., Hara, M., Chan, L. Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc. Natl. Acad. Sci. USA 101: 2458-2463, 2004.


  • DDS, 1990, Kyushu University, Oral Surgery
  • PhD, 1994, Kyushu University, Dentistry