Faculty Profile

Asish Ghosh
Section of Cardiology
Research Professor
Asish.Ghosh@bsd.uchicago.edu

Academic Interests

Dr. Ghosh’s major research interest focuses on the molecular, genetic, and epigenetic regulation of chronological and stress-induced accelerated cellular senescence and aging-associated cardiovascular disease. Using genetic and pharmacologic approaches, Dr. Ghosh originally demonstrated the essential role of a major epigenetic regulator, acetyltransferase p300 in profibrogenic signal-induced type I collagen synthesis and fibrogenesis. Dr. Ghosh and colleagues further defined the significance of physical and functional interaction of p300 with several pro-fibrotic and anti-fibrotic regulators/transcription factors in controlling profibrogenic signaling and the synthesis of type I collagen, a major extracellular matrix protein in the fibrotic tissues. Dr. Ghosh and colleagues also defined the pivotal role of deregulated plasminogen activator inhibitor-1 in cardiac fibrogenesis and in oxidative stress-induced cellular senescence/aging. Dr. Ghosh is interested to investigate the impact of epigenetics in stressor-induced cellular senescence, and cardiac aging in an animal model of atrial fibrillation, and the underlying mechanisms using biochemical, immunocytochemistry, immunohistochemistry, transcriptomics and proteomics approaches. His goal is to continue doing innovative research on cardiac aging in collaboration with experts in the field of aging research, and to provide excellent guidance in research to students and trainees.
 

Clinical Interests

 

Publications

  • Ghosh, A.K.,* Kalousdian, A., Shang ,M., Lux, E., Eren, M., Keating, A., Wilsbacher, L.D., Vaughan, D.E. Cardiomyocyte PAI-1 limits the extent of cardiac pathology in response to left ventricular pressure overload: insights from transcriptome analysis. Cell Signal. 104:110555, 2023.
  • Ghosh, A.K.* Acetyltransferase p300 is a putative epidrug target for amelioration of cellular aging-related cardiovascular disease. Cells 10, 2839, 2021.
  • Rai, R., Sun, T., Ramirez, V., Lux, E., Vaughan, D.E., Ghosh, A.K.* Acetyltransferase p300 inhibitor reverses hypertension-induced cardiac fibrosis. J Cell Mol Med. 23:3026-3031, 2019.
  • Rai, R., Verma, S.K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L.D., Vaughan, D.E., Quaggin, SE., Ghosh, AK*. A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis. Epigenetics 12:1004-1013, 2017.
  • Ghosh, A.K.*, Rai, R., Park, K.E., Eren, M., Miyata, T., Wilsbacher, L.D., Vaughan, D.E. A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence:molecular basis. Oncotarget 7:72443-72457, 2016.
  • Ghosh, A.K.,* Bradham, W.S., Gleaves, L.A., De Taeye, B., Murphy, S.B., Covington, J.W., Vaughan, D.E. Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: Involvement of constitutive TGF-? signaling and endothelial-to-mesenchymal transition. Circulation 122:1200-1209, 2010.

Training

  • PhD, 1991, Calcutta University, Field of Study: Cytology & Genetics
  • Postdoctoral Fellowship, 1996, Chicago Medical School, Field of Study: Molecular Biology