Faculty Profile


Wenndy Hernandez
Section of Cardiology
Instructor of Medicine
whernand@medicine.bsd.uchicago.edu

Academic Interests

Dr. Hernandez is committed to deciphering the molecular mechanisms underlying cardiovascular diseases using genetics, particularly those that disproportionally afflict under-represented minorities. Her current research integrates advanced quantitative and computational methods and tools that utilize large-scale data to determine the underlying molecular mechanisms of ischemic and hemorrhagic stroke in African Americans. Her goal is to enhance the understanding of ischemic and hemorrhagic stroke in African Americans and create a system of precision medicine by conducting multidisciplinary research - from the molecular to clinical levels - and in conjunction with leading cardiovascular and neurosurgeon physicians, translate research findings from the lab into a clinical setting. She believes that translational research that integrates population-specific genomic variation and complexity has tremendous potential to reduce health disparities and improve clinical practice.
 

Clinical Interests

 

Publications

  • Hernandez W, Aquino-Michaels K, Drozda K, Patel S, Jeong Y, Takahashi H, Cavallari LH, Perera MA. Novel single nucleotide polymorphism in CYP2C9 is associated with changes in warfarin clearance and CYP2C9 expression levels in African Americans. Transl Res. 2015 Jun;165(6):651-7. doi: 10.1016/j.trsl.2014.11.006. Epub 2014 Nov 22. PubMed PMID: 25499099; PubMed Central PMCID: PMC4433569
  • Hernandez W, Gamazon ER, Aquino-Michaels K, Patel S, O'Brien TJ, Harralson AF, Kittles RA, Barbour A, Tuck M, McIntosh SD, Douglas JN, Nicolae D, Cavallari LH, Perera MA. Ethnicity-specific pharmacogenetics: the case of warfarin in African Americans. Pharmacogenomics J. 2014 Jun;14(3):223-8. doi: 10.1038/tpj.2013.34. Epub 2013 Sep 10. PubMed PMID: 24018621; PubMed Central PMCID: PMC4016191.
  • Hernandez W, Gamazon ER, Smithberger E, O'Brien TJ, Harralson AF, Tuck M, Barbour A, Kittles RA, Cavallari LH, Perera MA. Novel genetic predictors of venous thromboembolism risk in African Americans. Blood. 2016 Apr 14;127(15):1923-9. doi: 10.1182/blood-2015-09-668525. Epub 2016 Feb 17. PubMed PMID: 26888256; PubMed Central PMCID: PMC4832509
  • Benn-Torres J, Bonilla C, Robbins CM, Waterman L, Moses TY, Hernandez W, Santos ER, Bennett F, Aiken W, Tullock T, Coard K, Hennis A, Wu S, Nemesure B, Leske MC, Freeman V, Carpten J, Kittles RA. Admixture and population stratification in African Caribbean populations. Ann Hum Genet. 2008 Jan;72(Pt 1):90-8. Epub 2006 Oct 1. PubMed PMID: 17908263.
  • Hernandez W, Gamazon ER, Aquino-Michaels K, Smithberger E, O'Brien TJ, Harralson AF, Tuck M, Barbour A, Cavallari LH, Perera MA. Integrated analysis of genetic variation and gene expression reveals novel variant for increased warfarin dose requirement in African Americans. J Thromb Haemost. 2017 Apr;15(4):735-743. doi: 10.1111/jth.13639. Epub 2017 Mar 25. PubMed PMID: 28135054
For a complete list of publications click here:

Training

  • BS, 1997, Mount Vernon College, Health Sciences
  • MS, 2004, Howard University, Human Genetics
  • PhD, 2012, The University of Chicago, Cancer Biology