Faculty Profile

Sonia Kupfer
Section of Gastroenterology
Associate Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730
Associate Director, Physician Scientist Development Program

Academic Interests

Dr. Kupfer's research is focused on the identification of genetic factors that contribute to risk of gastrointestinal diseases (including colorectal cancer, celiac disease and IBD) especially across different populations. In collaboration with Dr. Anna Di Rienzo, Professor in the Department of Human Genetics, she is investigating inter-individual and inter-ethnic differences in genetic and transcriptional responses to steroid hormones such as vitamin D and glucocorticoids. They are interested in how individuals respond to these hormones both in the peripheral blood and colon. Understanding these differences will help elucidate tissue-specific steroid hormone pathways as well as allow for individualized prediction of treatment response (e.g., glucocorticoid treatment in IBD or vitamin D treatment to prevent colorectal cancer). In collaboration with Dr. Nathan Ellis, Associate Professor at the University of Chicago Illinois, she is also studying genetic susceptibility factors to colorectal cancer specifically in African Americans who have the highest colorectal cancer incidence and mortality in the US. They have assembled a large series of patients from Chicago as well as North Carolina and are working to identify common as well as rare genetic variants that are associated with colorectal cancer in this population. Finally, she is interested in elucidating genetic and transcriptional signatures of celiac disease. To this end, she is collaborating with Dr. Bana Jabri on an experimental system to compare gene and gene expression differences in specific cell types involved in celiac disease pathogenesis.

Clinical Interests

Diagnosis and treatment of patients with genetic disorders such as hereditary gastrointestinal cancer syndromes and celiac disease.


For a complete list of publications click here:


  • BA, 1996, Yale University, German Studies
  • MD, 2001, University of Chicago, Medicine
  • Residency, 2004, University of Chicago,
  • Chief Resident, 2005, University of Chicago,
  • Fellowship, 2008, University of Chicago, Gastroenterology