Faculty Profile

Louis Philipson
Section of Endocrinology, Diabetes and Metabolism
Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730
James C. Tyree Professor of Diabetes Research and Care; Director,Kovler Diabetes Center

Academic Interests

Dr. Louis Philipson is a leading world authority on diabetes mellitus, and his research focuses on the biophysical, molecular and genetic aspects of insulin secretion, and monogenic diabetes. He was a co-discoverer of insulin gene mutations causing neonatal diabetes, a novel class of mutations causing diabetes through beta cell ER stress. These mutations are now known to be the second most common cause of permanent neonatal diabetes as well as rare causes of later onset diabetes. Dr. Philipson, together with his colleagues Drs Bell, Greeley and Naylor, is a resource for monogenic diabetes in the United States, following more than 100 patients diagnosed with neonatal diabetes and several hundred with MODY type diabetes. The team has also recently established the first United States registry for neonatal and monogenic diabetes. Dr. Philipson is co-director of the Human Islet Transplantation project at the University of Chicago. He has served as principal investigator on numerous research projects and has been widely published in biomedical journals including the Proceedings of the National Academy of Sciences, Science, Nature, Diabetes, American Journal of Physiology and the Journal of Biological Chemistry. Clinically he focuses on type 1 diabetes and complicated type 2 diabetes, monogenic diabetes and hypoglycemia. Currently President of the Chicago/Northern Illinois board of the American Diabetes Association and also a member of its National Board, he has been an invited speaker and presenter at scientific research conferences and symposia worldwide.

Clinical Interests

Diabetes, hypoglycemia, transplantation, and general endocrinology.


For a complete list of publications click here:


  • BA, 1976, Harvard University, Biochemistry
  • PhD, 1982, The University of Chicago, Biochemistry
  • MD, 1986, The University of Chicago,
  • Residency, 1990, The University of Chicago, Internal Medicine
  • Fellowship, 1991, The University of Chicago, Endocrinology, Diabetes and Metabolism