Faculty Profile

Bohao Chen
Section of Cardiology
Research Associate Professor
bchen@bsd.uchicago.edu

Academic Interests

Dr. Chen's research interests are focused on exploring the molecular mechanisms of airway constrictor hyperresponsiveness in asthma and searching for novel therapeutic approaches to this disease, including: 1). Determination of mechanisms that Gata5 deficiency causes airway constrictor hyperresponsiveness in mice; 2). Evaluation of the role of GATA5 in the regulation of Apo E-LDLR pathway in airway remodeling and constrictor hyperresponsiveness; 3). identification of the role of HLA-G in the activation of LILRB – SHP2 signaling pathway in airway inflammation and asthma; 4). Exploration of compounds that regulate contractile protein accumulation and modulate myofilament polymerization and/or reduce force generation in airway smooth muscle.
 

Clinical Interests

 

Publications

  • Chen, B., Stiff, P., Sloan, G., Kash, J., Manjunath, R., Pathasarathy, M., Oldenburg, D., Foreman, K. E. and Nickoloff, B. J. (2001) Replicative response, immunophenotype, and functional activity of monocyte-derived versus CD34(+)-derived dendritic cells following exposure to various expansion and maturational stimuli. Clin Immunol. 98, 280-292
  • Chen, B., Liu, G., Shardonofsky, F., Dowell, M., Lakser, O., Mitchell, R. W., Fredberg, J. J., Pinto, L. H. and Solway, J. (2006) Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice. J Appl Physiol. 101, 249-255
  • Pinto, L. H., Eaton, E., Chen, B., Fleisher, J., Shuster, D., McCauley, J., Kedainis, D., Siepka, S. M., Shimomura, K., Song, E. J., Husain, A., Lakser, O. J., Mitchell, R. W., Dowell, M. L., Brown, M., Camoretti-Mercado, B., Naclerio, R., Sperling, A. I., Levin, S. I., Turek, F. W. and Solway, J. (2008) Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness. Mamm Genome. 19, 2-14
  • Chen, B., Yates, E., Huang, Y., Kogut, P., Ma, L., Turner, J. R., Tao, Y., Camoretti-Mercado, B., Lang, D., Svensson, E. C., Garcia, J. G., Gruber, P. J., Morrisey, E. E. and Solway, J. (2009) Alternative promoter and GATA5 transcripts in mouse. Am J Physiol Gastrointest Liver Physiol. 297, G1214-1222
  • Chen, B., Hsu, R., Li, Z., Kogut, P. C., Du, Q., Rouser, K., Camoretti-Mercado, B. and Solway, J. (2012) Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif. Biochem J. 446 (1), 89-98.
For a complete list of publications click here:

Training

  • MD, 1985, Hubei Medical College, Medicine
  • MS, 1988, Tongji Medical University, Pathology
  • MS, 2002, Loyola University, Computer Science
  • Fellowship, 2005, The University of Chicago, Pulmonary Medicine