Faculty Profile

Michelle Le Beau
Section of Hematology / Oncology
Professor of Medicine
Arthur and Marian Edelstein Professor; Director, The University of Chicago Comprehensive Cancer Center; Director, Cancer Cytogenetics Laboratory

Academic Interests

Dr. Le Beau’s research focuses on the molecular analysis of the recurring chromosomal abnormalities in human leukemias and lymphomas, correlating specific abnormalities with morphological and clinical features and the development of risk-adapted therapy. Ongoing projects include the molecular cloning of a myeloid leukemia-related gene involved in the –5/del(5q) characteristic of therapy-related acute myeloid leukemia; genetic characterization of murine models recapitulating the genetic mutations in acute myeloid leukemia and identification of secondary, cooperating mutations and genetic pathways to leukemogenesis; and the application of murine models for pre-clinical drug testing and elucidation of the mechanism for the genetic instability characteristic of chromosomal fragile sites.

Clinical Interests



For a complete list of publications click here:


  • BS, 1976, Purdue University, Genetics
  • MS, 1978, University of Illinois, Pathology
  • PhD, 1981, University of Illinois, Pathology
  • Fellowship, 1983, The University of Chicago, Hematology/Oncology