Faculty Profile


Dianne Deplewski
Section of Endocrinology, Diabetes and Metabolism
Associate Professor of Medicine
ddeplews@peds.bsd.uchicago.edu
Referring Physician Access Line: 1-877-DOM-2730

Academic Interests

Dr. Deplewski is studying the biologic and molecular basis of the growth of the sebaceous gland, using the rat preputial gland as a model. She examines the effects of retinoic acid analogs and androgens on the growth of preputial cells in culture and the effect of the stromal-epithelial interface on the growth and ultrastructure of sebaceous cells in monolayer and lifted-raft culture. She examines the expression of 5?-reductase in sebaceous cells the peroxisomal proliferator activated receptors in sebaceous cells, which is a focus of the grant in which she is a co-investigator. Future directions of research are to further studies on the role of GH and IGFs in preputial cell growth and development. Specifically, she will attempt to delineate the direct and indirect effect of GH in the sebaceous gland system by utilizing antibodies against IGFs, and by measuring the levels of the IGFs and IGF binding proteins in cell culture media.
 

Clinical Interests

Pediatric endocrinology
 

Publications

For a complete list of publications click here:

Training

  • BS, 1982, Northwestern U., Biochemistry
  • MD, 1986, U. Illinois, Medicine