Faculty Profile

Fredric Coe
Section of Nephrology
Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730
Co-Director, Kidney Stone Program; Director, Clinical Research Training Program

Academic Interests

Dr. Fredric Coe collaborates with Drs. Elaine Worcester and Ben Ko within the kidney stone PPG concerning effects of altered sodium and acid base balance on renal mineral transport as assessed by a mixture of standard CRC based clearance methods, assessment of proximal tubule reabsorption via use of endogenous lithium clearances, and selected urine exosome renal transporter proteins as an index of tubule regulation via altered membrane transporter abundances. With others in the PPG – Drs. Lingeman, and Williams (IUPUI Campus) he collaborates on research concerning renal papillary abnormalities in kidney stone patients as assessed by a mixture of intraoperative digital imaging and specialized study of biopsy tissue obtained at the time of kidney stone surgery. With Dr. Anna Zisman, he collaborates in studies of racial differences of urine kidney stone risk factors, papillary changes as evidenced by intraoperative images obtained by Dr. Glenn Gerber at the University of Chicago (Urology), and regulation of proximal tubule transport in patients with stage 3 CKD as compared to healthy individuals. With Dr. Hammes, he has collaborated on studies of risk factors of vascular access graphs in hemodialysis patients.

Clinical Interests

Prevention and treatment of kidney stones. Dr. Coe has an educational website for both clinicians and patients that receives over 60,000 visits each month. Topics that are covered range from normal renal physiology to the cause of particular renal stone formation in humans. The website can be viewed here: http://kidneystones.uchicago.edu/  


  • Evan AP, Coe FL, Lingeman JE, Bledsoe SB, Worcester EM. Randall's Plaque in Stone Formers Originates in Ascending Thin Limbs. Am J Physiol Renal Physiol. 2018 Aug 1. doi: 10.1152/ajprenal.00035.2018. [Epub ahead of print] PubMed PMID: 30066583.
  • Bergsland KJ, Coe FL, Parks JH, Asplin JR, Worcester EM. Evidence for a role of PDZ domain-containing proteins to mediate hypophosphatemia in calcium stone formers. Nephrol Dial Transplant. 2018 May 1;33(5):759-770. doi: 10.1093/ndt/gfx284. PubMed PMID: 29126251.
  • Williams JC Jr, Borofsky MS, Bledsoe SB, Evan AP, Coe FL, Worcester EM, Lingeman JE. Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease. J Urol. 2018 Jan;199(1):186-192. doi: 10.1016/j.juro.2017.08.063. Epub 2017 Aug 16. PubMed PMID: 28822796; PubMed Central PMCID: PMC5871923
  • Javid Mahmoudzadeh Akherat SM, Cassel K, Boghosian M, Hammes M, Coe F. A Predictive Framework to Elucidate Venous Stenosis: CFD & Shape Optimization. Comput Methods Appl Mech Eng. 2017 Jul 1;321:46-69. doi: 10.1016/j.cma.2017.03.036. Epub 2017 Apr 10. PubMed PMID: 28649146; PubMed Central PMCID: PMC5479643.
  • Worcester EM, Bergsland KJ, Gillen DL, Coe FL. Mechanism for higher urine pH in normal women compared with men. Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F623-F629. doi: 10.1152/ajprenal.00494.2017. Epub 2017 Dec 20. PubMed PMID: 29357436; PubMed Central PMCID: PMC5966764
For a complete list of publications click here:


  • BA, 1955, The University of Chicago,
  • BS, 1957, The University of Chicago, Physiology
  • MD, 1961, The University of Chicago,
  • Residency, 1964, Michael Reese Hospital, Medicine
  • Residency, 1965, Michael Reese Hospital, Chief Resident
  • Fellowship, 1969, University of Texas, Nephrology