Faculty Profile


Bohdan Khomtchouk
Section of Computational Biomedicine and Biomedical Data Science
Instructor of Medicine
bohdan@uchicago.edu

Academic Interests

Dr. Khomtchouk's research program concerns the emerging field of cardioinformatics, working at the nexus of bioinformatics and precision cardiology, with the goal of integrating computational biology and AI/machine learning-based approaches to illuminate cardio-(vascular/renal/metabolic) biology and enable new therapeutics. Dr. Khomtchouk is the founder of Dock Therapeutics, a biotech spinoff company borne out of his lab during the NSF i-Corps program hosted through the UChicago Polsky Center for Entrepreneurship and Innovation and Booth School of Business. His lab's principal research focus is on creating biomedical infrastructure platforms that provide powerful query and browsing interfaces between data and user, with the primary goal of enabling computationally-derived therapeutics. Dr. Khomtchouk is also a principal investigator of the HeartBioPortal project, the world’s largest human cardiovascular and cerebrovascular disease genetics database, which enables gene and variant-level search across various heart disease and stroke phenotypes for the broader research community. Given his translational research interests, Dr. Khomtchouk is a strong advocate of the need to not only bridge the "bench-to-bedside" divide, but also the "informatics-to-medicine" divide, and has previously been involved in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Program (Atherosclerosis Working Group) and served as a Research Associate in the VA Palo Alto Healthcare System working on cardiovascular genomics in Korean and Vietnam War veterans enrolled in the Million Veteran Program. Dr. Khomtchouk previously served as an American Heart Association (AHA) Postdoctoral Fellow in the Department of Biology and Department of Medicine (Division of Cardiovascular Medicine) at Stanford University.
 

Clinical Interests

 

Publications

  • Khomtchouk BB, Vand KA, Koehler WC, Tran DT, Middlebrook K, Sudhakaran S, Nelson CS, Gozani O, Assimes T: “HeartBioPortal: An Internet-of-Omics for Human Cardiovascular Disease Data." Circulation: Genomic and Precision Medicine. 2019, 12(4):e002426. doi: 10.1161/CIRCGEN.118.002426
  • Khomtchouk BB, Nelson CS, Vand KA, Palmisano S, Grossman RL: “HeartBioPortal2.0: new developments and updates for genetic ancestry and cardiometabolic quantitative traits in diverse human populations.” Database. 2020, baaa115. doi: 10.1093/database/baaa115
  • Khomtchouk BB, Tran DT, Vand KA, Might M, Gozani O, Assimes TL: “Cardioinformatics: the nexus of bioinformatics and precision cardiology." Briefings in Bioinformatics. 2020, 21(6), 2031--2051. doi: 10.1093/bib/bbz119
  • Khomtchouk BB, Nonner W: “Gaussian-distributed codon frequencies of genomes." G3: Genes, Genomes, Genetics. 2019, 9(5): 1449--1456. doi: 10.1534/g3.118.200939
  • Gidlöf O, Johnstone AL, Bader K, Khomtchouk BB, O’Reilly JJ, Celik S, Van Booven DJ, Wahlestedt CR, Metzler B, Erlinge D: “Ischemic preconditioning confers epigenetic repression of Mtor and induction of autophagy through G9a-dependent H3K9 di-methylation.” Journal of the American Heart Association. 2016, 5:12. doi: 10.1161/JAHA.116.004076
For a complete list of publications click here:

Training

  • BS, 2013, Benedictine University, Mathematics (summa cum laude)
  • BS, 2013, Benedictine University, Physics (summa cum laude)
  • BS, 2013, Benedictine University, Molecular Biology & Biochemistry (summa cum laude)
  • PhD, 2017, University of Miami (Miller School of Medicine), Computational Human Genetics and Genomics
  • Fellowship, 2019, Stanford University, AHA Postdoctoral Fellowship