Faculty Profile


Bohdan Khomtchouk
Section of Computational Biomedicine and Biomedical Data Science
Instructor of Medicine
bohdan@uchicago.edu

Academic Interests

Dr. Khomtchouk's research concerns the emerging field of cardioinformatics, working at the nexus of bioinformatics and cardiology. His principal research focus is on creating artificial intelligence and machine learning software to organize and better understand the world's cardiovascular disease knowledge (text and data) at a massive scale -- working at the multidisciplinary interface of healthcare, algorithm design, software engineering, integrative bioinformatics, multi-omics, natural language processing, and statistical learning. Dr. Khomtchouk was previously involved in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Program (Atherosclerosis Working Group) and served as a Research Associate in the VA Palo Alto Healthcare System working on the Million Veteran Program. Dr. Khomtchouk previously served as an American Heart Association (AHA) Postdoctoral Fellow in the Department of Biology and Department of Medicine (Division of Cardiovascular Medicine) at Stanford University.
 

Clinical Interests

 

Publications

  • *Barbier E, *Johnstone AL, Khomtchouk BB, Tapocik JD, Pitcairn C, Rehman FA, Augier E, Borich A, Schank JR, Rienas CA, Van Booven DJ, Hui S, Nätt D, Wahlestedt C, Heilig M: “Dependence-induced increased of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2.” Molecular Psychiatry. 2017, 22: 1746--1758. (* indicates joint-first author) http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2016131a.html
  • Khomtchouk BB, Nonner W: “Gaussian-distributed codon frequencies of genomes." G3 (Bethesda). 2019, 9(5): 1449--1456. https://doi.org/10.1534/g3.118.200939
  • Khomtchouk BB, Hennessy JR, Wahlestedt C: “MicroScope: ChIP-seq and RNA-seq software analysis suite for gene expression heatmaps.” BMC Bioinformatics. 2016, 17:390. https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-016-1260-x
  • Gidlöf O, Johnstone AL, Bader K, Khomtchouk BB, O’Reilly JJ, Celik S, Van Booven DJ, Wahlestedt CR, Metzler B, Erlinge D: “Ischemic preconditioning confers epigenetic repression of Mtor and induction of autophagy through G9a-dependent H3K9 di-methylation.” Journal of the American Heart Association. 2016, 5:12, pp. 1--27. http://jaha.ahajournals.org/content/5/12/e004076
  • Khomtchouk BB, Vand KA, Koehler WC, Tran DT, Middlebrook K, Sudhakaran S, Nelson CS, Gozani O, Assimes T: “HeartBioPortal: An Internet-of-Omics for Human Cardiovascular Disease Data." Circulation: Genomic and Precision Medicine. 2019, 12(4):e002426. doi: 10.1161/CIRCGEN.118.002426
For a complete list of publications click here:

Training

  • BS, 2013, Benedictine University, Molecular Biology & Biochemistry (summa cum laude); Mathematics (summa cum laude); and Physics (summa cum laude)
  • PhD, 2017, University of Miami (Miller School of Medicine), Computational Human Genetics and Genomics
  • Fellowship, 2019, Stanford University, AHA Postdoctoral Fellowship