Faculty Profile


Angela Lager
Section of Hematology / Oncology
Assistant Professor of Medicine
alager@medicine.bsd.uchicago.edu

Academic Interests

Dr. Lager’s research and clinical interests are focused on using clinical cytogenetic and molecular genetic modalities for the investigation and discovery of neoplasm-associated genetic abnormalities. She’s interested in employing sophisticated clinical laboratory diagnostics toward discovery of novel disease markers, and using these markers for patient prognosis and treatment stratification.
 

Clinical Interests

 

Publications

  • Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, Karl RT, Maeda T, Miller RH, Tesar PJ. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol. 2013 May; 31(5):426-33. PMID: 23584611
  • Unique aspects of sequence variant interpretation for inborn errors of metabolism (IEM): The ClinGen IEM Working Group and the Phenylalanine Hydroxylase Gene. Zastrow DB, Baudet H, Shen W, Thomas A, Si Y, Weaver MA, Lager AM, Liu J, Mangels R, Dwight SS, Wright MW, Dobrowolski SF, Eilbeck K, Enns GM, Feigenbaum A, Lichter-Konecki U, Lyon E, Pasquali M, Watson M, Blau N, Steiner RD, Craigen WJ, Mao R. Unique aspects of sequence variant interpretation for inborn errors of metabolism (IEM): The ClinGen IEM Working Group and the Phenylalanine Hydroxylase Gene. Hum Mutat. 2018 11; 39(11):1569-1580. PMID: 30311390
  • Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells. Lager AM, Corradin OG, Cregg JM, Elitt MS, Shick HE, Clayton BLL, Allan KC, Olsen HE, Madhavan M, Tesar PJ. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells. Nat Commun. 2018 09 13; 9(1):3708. PMID: 30213958
  • Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease. Elitt MS, Shick HE, Madhavan M, Allan KC, Clayton BLL, Weng C, Miller TE, Factor DC, Barbar L, Nawash BS, Nevin ZS, Lager AM, Li Y, Jin F, Adams DJ, Tesar PJ. Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease. Stem Cell Reports. 2018 09 11; 11(3):711-726. PMID: 30146490
  • Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis. Zechel JL, Doerner SK, Lager A, Tesar PJ, Heaney JD, Nadeau JH. Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis. BMC Genet. 2013 Jun 17; 14:54. PMID: 23773267

Training

  • BA, 2010, Saint Mary's University, Biology
  • PhD, 2015, Case Western Reserve University, Genetics
  • Fellow, 2017, University of Wisconsin-Madison, Clinical Cytogenetic
  • Fellow, 2018, University of Wisconsin-Madiison, Molecular Genetic