Faculty Profile

Arlene Chapman
Section of Nephrology
Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730
Chief, Section of Nephrology

Academic Interests

Dr. Chapman's research focuses on clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD). Dr. Chapman has been heavily involved in the development of novel imaging biomarkers for this disease using magnetic resonance imaging and calculating total kidney volume (TKV). Clinical trials testing appropriate levels of blood pressure control, inhibition of the vasopressin V2 receptor, epidermal growth factor receptor inhibition and alterations in fluid intake and dietary amino acids and their impact on disease progression are currently active.. Dr. Chapman also studies personalized or precision medicine and the role that genetic background plays in predicting antihypertensive responses to blood pressure medications used to treat hypertension as well as disease progression in ADPKD. Dr. Chapman's early investigations centered on demonstrating that the renal and systemic changes that occur during pregnancy happen early, by the sixth week of pregnancy. She has received continuous funding for her work from the National Institutes of Health (NIH) over the past 20 years.

Clinical Interests

Hereditary renal diseases, specifically autosomal dominant polycystic kidney disease, as well as other rare conditions including autosomal recessive kidney diseases, the CAKUT disorders, ciliopathies, tuberous sclerosis complex and von Hippel Lindau disease.


For a complete list of publications click here:


  • MD, 1983, McMaster University,
  • Internship, 1984, Georgetown University Hospital, Internal Medicine
  • Residency, 1986, Georgetown University Hospital, Internal Medicine
  • Fellowship, 1987, Georgetown University Hospital, Nephrology
  • Fellowship, 1988, Georgetown University Hospital, Nephrology
  • Fellowship, 1989, University of Colorado Health Sciences Center, Nephrology