Faculty Profile

Randy Sweis
Section of Hematology / Oncology
Assistant Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730

Academic Interests

Dr. Sweis is a physician-scientist working to identify and circumvent mechanisms of resistance to cancer immunotherapies. His laboratory research is focused on modulating the tumor microenvironment to facilitate anti-tumor immune responses, using mouse models of bladder and skin cancers. In the clinic, he uses his expertise in developmental therapeutics and clinical pharmacology to investigate biomarkers and novel therapeutic strategies to improve immunotherapy efficacy in patients.

Clinical Interests

Treatment of patients with genitourinary malignancies including bladder, kidney, prostate, and testicular cancers.


  • Sweis RF, Spranger S, Bao R, Paner GP, Stadler WM, Steinberg G, Gajewski TF. Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer. Cancer Immunol Res. 2016;4(7):563-8. doi: 10.1158/2326-6066.CIR-15-0274. PubMed PMID: 27197067; PMCID: PMC4943758.
  • Sweis RF, Drazer MW, Ratain MJ. Analysis of Impact of Post-Treatment Biopsies in Phase I Clinical Trials. J Clin Oncol. 2016;34(4):369-74. doi: 10.1200/JCO.2015.63.6126. PubMed PMID: 26668350.
  • Sweis RF, Medved M, Towey S, Karczmar GS, Oto A, Szmulewitz RZ, O'Donnell PH, Fishkin P, Stadler WM. Dynamic Contrast Enhanced-Magnetic Resonance Imaging as a Pharmacodynamic Biomarker for Pazopanib in Metastatic Renal Carcinoma. Clin Genitourin Cancer. 2016. doi: 10.1016/j.clgc.2016.08.011. PubMed PMID: 27634566.
  • Sweis RF and Galsky MD. Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/ biomarkers. Urol Oncol. 2016;34(12):556-65. Epub 2016/11/09. doi: 10.1016/j.urolonc.2016.10.006. PubMed PMID: 27836246.
  • Sweis RF, Luke JJ. Mechanistic and pharmacologic insights on immune checkpoint inhibitors. Pharmacol Res. 2017;120:1-9. Epub 2017/03/18. doi: 10.1016/j.phrs.2017.03.012. PubMed PMID: 28323141.
For a complete list of publications click here:


  • BS, 2004, University of Chicago, Biological Chemistry
  • MD, 2010, University of Chicago, Medicine
  • Residency, 2013, University of Michigan, Internal Medicine
  • Fellowship, 2016, University of Chicago, Hematology/Oncology
  • Fellowship, 2017, University of Chicago, Clinical Pharmacology & Pharmacogenomics