Faculty Profile


Jonathan Grinstein
Section of Cardiology
Assistant Professor of Medicine
Referring Physician Access Line: 1-877-DOM-2730

Academic Interests

Jonathan Grinstein, MD, FACC is an advanced heart failure physician and Director of Mechanical Circulatory Support at The University of Chicago. He is an Assistant Professor of Medicine at The University of Chicago School of Medicine and a member of the Alpha Omega Alpha Medical Society and the Gold Humanism Honor Society. Dr. Grinstein participates in novel research involving LVADs. In lieu of a physical examination or an invasive right heart catheterization procedure, Dr. Grinstein has researched, perfected, and currently utilizes an echocardiographic and computed tomography technique to noninvasively monitor the pressure and volume inside the heart of individuals with an implanted LVAD. This technique allows cardiologists to analyze how well a patient is responding to the device and make necessary adjustments in real time. He has also conducted research to develop a “smart” LVAD that can intuitively adjust its speed based on the physiological needs of the patient. He is also using computational fluid dynamics, a novel technology integrating engineering and physiology, to study flow through the LVAD in an attempt to best match the technology to meet the physiologic needs of the patient
 

Clinical Interests

Advanced Heart Failure,Mechanical Circulatory Support,Cardiogenic Shock,Cardiac Transplantation
 

Publications

  • Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Jorde UP, Juricek C, Ota T, Jeevanandam V, Lang RM, Uriel N. "Accurate Quantification Methods for Aortic Insufficiency Severity in Patients With LVAD: Role of Diastolic Flow Acceleration and Systolic-to-Diastolic Peak Velocity Ratio of the Outflow Cannula." JACC: Cardiovascular Imaging (2016)
  • Grinstein J, Kruse E, Sayer G, Fedson S, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Lang RM, Uriel N. "Novel Echocardiographic Parameters of Aortic Insufficiency in Continous Flow Left Ventricular Assist Devices and Clinical Outcome." Journal of Heart and Lung Transplantation (2016)
  • Grinstein J, Rodgers D, Kalantari S, Sayer G, Kim GH, Sarswat N, Adatya S, Ota T, Jeevanandam, Burkhoff, D , Uriel N. "HVAD Waveform Analysis as a Non-Invasive Marker of Pulmonary Capillary Wedge Pressure: A First Step towards the Development of a Smart Left Ventricular Assist Device." ASAIO Journal (2018)
  • Grinstein J, Imamura T, Kruse E, Kalantari S, Rodgers D, Adatya S, Sayer G, Kim GH, Sarswat N, Raihkelkar J, Ota T, Jeevanandam V, Burkhoff D, Lang R, Uriel N. "Echocardiographic Predictors of Hemodynamics in Patients Supported with Left Ventricular Assist Devices." Journal of Cardiac Failure (2018)
  • Grinstein J, Kruse E, Sayer G, Kim GH, Raikhelkar J, Kalantari S, Sarswat N, Adatya S, Ota T, Jeevanandam V, Mor-Avi V, Lang RM, Uriel N. "Outflow Cannula Systolic Slope in Patients With Left Ventricular Assist Devices: A Novel Marker of Myocardial Contractility." ASAIO Journal (2018)

Training

  • MD, 2010, University of Chicago School of Medicine, Medicine
  • Residency, 2013, Harvard Medical School, Brigham and Women's Hospital, Internal Medicine
  • Fellowship, 2016, University of Chicago Medical Center, Cardiology
  • Fellowship, 2016, University of Chicago Medical Center, Advanced Heart Failure